Relationship of high-sensitivity C-reactive protein and carotid artery atherosclerosis with acute cerebral infarction
10.3760/cma.j.issn.0254-9026.2010.08.004
- VernacularTitle:高敏C-反应蛋白及颈动脉粥样硬化与急性脑梗死的关系
- Author:
Xiangfeng KONG
;
Ming CHEN
;
Ping WANG
- Publication Type:Journal Article
- Keywords:
Cerebrovascular accident;
C-reactive protein;
Carotid artery diseases
- From:
Chinese Journal of Geriatrics
2010;29(8):629-631
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate and analyze the relationship of the level of high-sensitivity C-reactive protein (hs-CRP) and carotid artery atherosclerosis with acute cerebral infarction (ACI).Methods Fifty-nine patients with ACI were assigned as experimental group and thirty healthy people as control group. The serum level of hs-CRP was measured, and the carotid plaques and the changes of carotid intimal-medial thickness (IMT) were examined by color Doppler ultrasonography.Then the relationship between the serum level of hs-CRP and the severity of disease was analyzed.Results The serum level of hs-CRP was higher in ACI group than in control group [(5.96± 1.52)mg/L vs. (1.78±1.02) mg/L, t=15.383, P＜0.01]. The detection rates of carotid plaques and the increased carotid IMT were higher in ACI group than in control group [77.97% vs. 36.67%, x2 =12.92, P＜0.01; (1.18±0.17) mm vs. (1.02±0.15) mm, t=4.544, P＜0.05]. The hs-CRP levels were higher in the severe cases [(15.68±1.45) mg/L] than in moderate cases [(4.16±1.39)mg/L] and mild cases [(1.88±0.34) mg/L, t=37. 217, 25. 243, both P＜0.01]. Conclusions The elevated levels of hs-CRP have overt clinical significances for the atherothrombotic cerebral infarction. Early determination of hs-CRP is helpful to evaluate patient's condition and prognosis.
