Expressions of estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2 and relationships of these expressions with clinical pathology in breast cancer patients aged 70 years old and over
10.3760/cma.j.issn.0254-9026.2010.08.009
- VernacularTitle:70岁及以上乳腺癌患者雌孕激素受体和表皮生长因子受体-2表达与病理的关系
- Author:
Ping ZHANG
;
Li DING
;
Xin NIE
;
Lin LI
;
Meizhen ZHOU
- Publication Type:Journal Article
- Keywords:
Breast cancer;
Receptors,estrogen;
Progestins;
Receptor,epidermal growthfactor
- From:
Chinese Journal of Geriatrics
2010;29(8):644-647
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expressions of estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER-2) and relationships of these expressions with the clinicopathology in breast cancer patients aged 70 years old and over. Methods The expressions of ER, PR and HER-2 were detected by immunohistochemical staining from 124 elderly breast cancer patients, and the relationships of these expressions with pathological classification, tumor size, lymph node metastasis and TNM stage were analyzed. Results Among 124 patients, the positive expression rate of ER and PR was 75.0% (93/124) and 71.0% (88/124),respectively. They were not associated with pathological classification, tumor size, lymph node metastasis or TNM stage (all P＞0. 05). The positive expression rate of Her-2(+++) and Her-2 (++) was 11.3% (14/124) and 24.2% (30/124), respectively. And the expression of Her-2 was significantly associated with tumor size, lymph node metastasis and TNM stage (P＜0. 05) but not with pathological classification (P＞0. 05). Conclusions The positive expressions of ER and PR are not correlated with the clinicopathology in elderly breast cancer patients. Her-2 overexpression is positively associated with tumor size, lymph node metastasis and TNM stage.
