Significance of detecting human papillomaviral DNA in cervical disease
10.3760/cma.j.issn.1008-6706.2010.14.007
- VernacularTitle:HPV-DNA在宫颈疾病检测中的意义
- Author:
Qingen SONG
;
Hongying MA
- Publication Type:Journal Article
- Keywords:
Human papillomaviral DNA;
Uterine cervix cancer;
Cervical intraepithelial neoplasia
- From:
Chinese Journal of Primary Medicine and Pharmacy
2010;17(14):1885-1886
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the detection and significance of human papillomaviral DNA(HPV-DNA) in cervical disease. Methods The express of HPV-DNA were detected by hybrid capture 2 in the patients with chronic cervicitis ( n = 166), cervical intraepithelial neolasia ( GIN ) ( n = 89 ) and uterine cervix cancer ( UCC ) ( n = 23 ). Results The positive expression rate of HPV-DNA in GIN Ⅰ , Ⅱ , Ⅲ grade and UCC were 70.8% (17/24) ,79. 3% (23/29) ,88.9% (32/36) ,91. 3% (21/23). They were significantly higher than those in chronic cervicitis 30.7% (51/166) (P ＜ 0. 01 );As the development of cervical disease, HPV-DNA positive expression had increasing trend.Conclusion The detection of HPV-DNA had an important role for the early UCC screening,prevention and treatment.
