Therapeutic effects of alendronate combined with Caltrate D on regional bone mineral density in elderly type 2 diabetic women with osteoporosis
10.3760/cma.j.issn.0254-9026.2010.08.011
- VernacularTitle:阿伦膦酸盐联合钙尔奇D对老年女性2型糖尿病骨质疏松患者骨密度的影响
- Author:
Hailing CHEN
;
Lili DENG
;
Jufen LI
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,type 2;
Osteoporosis,postmenopausal;
Diphosphonates
- From:
Chinese Journal of Geriatrics
2010;29(8):652-655
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the therapeutic effects of alendronate combined with Caltrate D on regional bone mineral density (BMD) in elderly type 2 diabetic women with osteoporosis. Methods Thirty-four elderly type 2 diabetic women with osteoporosis aged 60-79 years (average 68. 0±4.5 years), with body mass index (BMI) of (25.0±3.7) kg/cm2 and duration of diabetes (8.9 ±4.4) years were enrolled. At the basis of a comprehensive management, the patients were treated with alendronate combined with Caltrate D for 6 months. BMD of the lumbar spine and hip, several biochemical indexes were measured before and after treatment. Results After the 6 months treatment, the BMD of different regions at lumbar spine and hip all increased. The T value and BMD were significantly higher at lumbar spines than at hip (both P＜0.01). The differences of T value and BMD of different regions were significant (P = 0.003 and 0.005,respectively). BMD percent change at lumbar spine were L4 (44.7%) ＞ L3 (31.9%) ＞ L total (27.3 % ) ＞ L1 (20.0%) ＞ L2 (14.3 % ), and the BMD percent changes were significantly higher in L3 and L4 than in other regions at lumbar spine (P=0. 038 and 0. 008, respectively). The changes of T value and BMD were significantly higher in L3, L total, L1 and L4 than in L2 (T value: P=0. 036,0. 042, 0. 006 and 0. 004, respectively; BMD: P=0. 002, 0. 002, 0. 003 and 0. 001, respectively).Conclusions On the basis of comprehensive management, the 6 months treatment with alendronate combined with Caltrate D in elderly type 2 diabetic women with osteoporosis may achieve good therapeutic effect at lumbar spines, especially at the lower lumbar spines, while less effective at hip.
