Clinical application of Cystatin C-based eGFR equations in the estimation of glomerular filtration rate in elderly type 2 diabetic patients
10.3760/cma.j.issn.0254-9026.2010.08.014
- VernacularTitle:新胱抑素C-肾小球滤过率公式在老年糖尿病肾病患者中的应用
- Author:
Yajie ZHAO
;
Yongju ZHAO
;
Linhui SHEN
;
Wei WANG
;
Binyu LUO
;
Jie MIAO
;
Meizhu YAN
;
Danying YANG
- Publication Type:Journal Article
- Keywords:
Diabetic nephropathies;
Glomerular filtration rate;
Cysteine proteinase inhibitors;
C-reactive protein
- From:
Chinese Journal of Geriatrics
2010;29(8):662-666
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the most suitable equation in accessing renal function for the elderly type 2 diabetic patients, and its clinical utility in combination with hypersensitive C-reactive protein (hsCRP). Methods The new Cystatin C-based equations for estimated glomerular filtration rate (Cys-eGFR) and conventional predictive equations were compared with isotopic GFR (iGFR) by linear regression analysis, paired t-test, Bland and Altman procedures and non-parametric receiver operating characteristic (ROC) curves. The new Cys-eGFR equation and hsCRP were also incorporated for detecting renal disease in this population. Results The new Cys-eGFR equation had a better relativity with iGFR (r= 0.767, P＜0.001), a less bias (bias: 0.0007, P＞0.05), a higher conformance (2SD: 21.56), higher sensitivity (90.7%) and specificity (88.6%) for diagnosing moderate decrease in renal function. There was a negative relationship between the new Cys-eGFR and hsCRP (r=-0.655, P＜0.01). When the new Cys-eGFR was 67.06 ml· min-1 ·1.73 m-2 and hsCRP was 5.65 mg/L, the combination of Cys-eGFR and hsCRP was better than the combination of serum creatinine and urine albumin/creatinine ratio in screening stage 3 chronic kidney disease (95%vs.46%). Conclusions The combination of new Cys-eGFR equation and hsCRP may screen an early decrease of moderate GFR.
