Safety of thyroidectomy combined with central lymph node dissection for papillary thyroid carcinoma: a meta-analysis

VernacularTitle:联合甲状腺全切除和中央区淋巴结清扫术治疗甲状腺乳头状癌安全性的meta分析
Author: Ye PAN ; Qi ZHENG ; Youben FAN ; Bo WU ; Xiaodong HAN
Publication Type:Journal Article
Keywords: Thyroid neoplasms; Neck dissection; Hypocalcemia; Vocal cord paralysis; Meta analysis
From: Chinese Journal of General Surgery 2010;25(8):631-634
CountryChina
Language:Chinese
Abstract: Objective To evaluate the safety of central lymph node dissection with total thyroidectomy for papillary thyroid carcinoma. Methods A meta-analysis on the data of suitable seven clinical researches was performed using the Mantel-Haenszel method and the risk difference was calculated.Results Seven studies with a total of 1524 patients were eligible for inclusion, 620 were with totalthyroidectomy plus central lymph node dissection and 904 with thyroidectomy alone. There was a significant increased risk of temporary hypocalcaemia ( P = 0. 03 ) and temporary vocal cord palsy ( P = 0. 01 ) when central lymph node dissection was performed in addition to a thyroidectomy. However, the risk of permanent hypocalcaemia( P = 0. 32 ) and permanent vocal cord palsy (P = 0. 75 ) has no statistical difference between the two groups. Conclusion Central neck dissection added to thyroidectomy does not increase rate of permanent morbidity in thyroid cancer patients.