Risk factors of antidepressant treatment emergent suicidal ideas or attempted suicide among patients with bipolar depression
10.3760/cma.j.issn.1674-6554.2010.08.015
- VernacularTitle:抗抑郁剂治疗过程中双相抑郁患者自杀意念、自杀未遂的风险因素分析
- Author:
Zili HAN
;
Zhaoyu GAN
;
Minfeng CHENG
;
Ming ZHANG
;
Zhiyong ZHONG
;
Xiaoli WU
;
Jinbei ZHANG
- Publication Type:Journal Article
- Keywords:
Bipolar depression;
Antidepressant;
Suicidal idea;
Attempted suicide
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2010;19(8):716-717
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the risk factors of antidepressant treatment emergent suicidal ideas or attempted suicide among patients with bipolar depression. Methods Out of 623 patients with bipolar disorder visiting between June 2006 and June 2009,68 who was initially diagnosed as unipolar disorder and treated with antidepressants were retrospectively surveyed. Suicide and activation symptoms during the process of antidepressant treatment were estimated based on the cases record and semi-structural interviews. Unconditional bivariate logistic regression was conducted to analyze the potential risk factors. Results Of 68 patients,7 ( 10. 3% ) experienced antidepressant treatment emergent suicidal ideas and 4 ( 5.9% ) attempted suicide after 2 to 63 ( 17.45 ± 5.90 )days following the treatment. The antidepressant treatment emergent suicidal ideas or attempted suicide were related to the suicidal level before treatment (P= 0. 012, OR = 2. 072 ) and the combined use of benzodiazepine (P =0. 043, OR = 0.236). Clinical subtypes, gender, age, symptoms feature, types of antidepressant and antidepressanttreatment emergent activation symptoms had little impact on the antidepressant treatment emergent suicidal ideas orattempted suicide (P ＞ 0.05 ). Conclusion The antidepressant treatment emergent suicidal ideas or attempted suicide among patients with bipolar depression are positively related to the suicidal level before treatment while negatively associated with the combined use of benzodiazepine.
