Immune reconstitution inflammatory syndrome and its risk factors in highly active antiretroviral therapy
10.3760/cma.j.issn.1674-2397.2010.04.006
- VernacularTitle:高效抗反转录病毒疗法中的免疫重建炎性综合征及相关危险因素分析
- Author:
Guoqiang ZHOU
;
Min WANG
;
Yuhuang ZHENG
;
Meng LIU
;
Gang XIAO
- Publication Type:Journal Article
- Keywords:
Acquired immunodeficiency syndrome;
Human immunodeficiency virus;
Highly active antiretroviral therapy;
Immune reconstitution inflammatory syndrome
- From:
Chinese Journal of Clinical Infectious Diseases
2010;03(4):213-216
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the incidence, clinical manifestation and risk factors of immune reconstitution inflammatory syndromes (IRIS) in highly active antirctroviral therapy (HAART) for HIV/AIDS patients. Methods Two hundred and twelve HIV/AIDS patients received HAART, and were followed up for 6 months. The incidence time and disease spectrum of IRIS were observed. Multiple logistic regression analysis was performed to identify the risk factors for IRIS. Results Among 212 patients, there were 59 (27.8%) experienced an IRIS event during the first 6 months of HAART, 2 of which died (2/59,3.39% ). Median time of IRIS onset was 21 days form HAART initiation. The disease spectrum included tuberculosis, herpes virus infections, pneumocystis jirovecii pneumonia, cryptococcal meningitis and penicillium marneffei infection. Risk factors of IRIS included baseline infections ( OR = 1. 655, P =0.010),fever during HAART ( OR = 2. 344, P= 0.006), and baseline CD4 + count ( OR = 1. 556, P = 0. 034).Conclusions IRIS usually occurred within the first month from HAART initiation, and tuberculosis and herpes virus infection are most common. The occurrence of IRIS is associated with the antigens burden and the decreased baseline CD4 + count.
