Role of TLR4 in liver failure caused by the damage of gut barrier
10.3760/cma.j.issn.1673-4203.2010.08.013
- VernacularTitle:TLR4在肠道屏障功能损伤致肝功能衰竭中的作用
- Author:
Xueyan WU
;
Peijian ZHANG
- Publication Type:Journal Article
- Keywords:
Dug barrier;
Liver failure;
Liver transplantation;
Toll-like receptor
- From:
International Journal of Surgery
2010;37(8):541-543
- CountryChina
- Language:Chinese
-
Abstract:
Toil-like receptors (TLRs) present in the cell membrane and are transmembrane receptors.TLR4 is a key member of the TLRs family involved in inflammatory response and recognizing microbes. Gut barrier mainly include mechanical, immunological, chemical and biological barrier four major sections. Liver transplantation leads to intestinal ischemia-reperfusion (I/R) injury, then intestinal bacteria and endotoxin translocate into the blood circulation and at the same time, I/R injury stimulates the release of a large number of endogenous molecules. TLR4 is combined with both endotoxin and endogenous ligand and promotes the release of multi-kinds of cytokines and inflammatory mediators, causing a series of inflammatory reactions,and even leading to liver failure.
