Neuron-specific enolase and high sensitivity C-reactive protein on neonatal hypoxic-ischemic encephalopathy's condition and prognosis

VernacularTitle:神经元特异性烯醇化酶和高敏C反应蛋白对新生儿缺氧缺血性脑病的病情及预后评价
Author: Wenyan CHEN ; Xuejie XU ; Yi LIU ; Furong LAN
Publication Type:Journal Article
Keywords: Phosphopyruvate hydratase; C-reactive protein; Hypoxia-ischemia,brain
From: Chinese Journal of Postgraduates of Medicine 2010;33(24):15-17
CountryChina
Language:Chinese
Abstract: Objective To investigate the serum neuron-specific enolase (NSE) and high sensitivity C-reactive protein (hs-CRP) on neonatal hypoxic-ischemic encephalopathy (HIE) in children with illness and prognosis of assessed value. Method The serum NSE, hs-CRP levels of 40 patients with HIE (HIE group) of the acute stage and convalescence, and 20 healthy neonates (control group ) were measured and the clinical sub-degree relationships were analyzed. Results The serum NSE, hs-CRP levels in HIE group of the acute stage [ (32.88 ± 12.61 ) μ g/L, (6.43 ± 2.07) mg/L] were significantly higher than those in control group [(8.62 ± 3.58) μ g/L, (2.61 ± 0.95) mg/L](P ＜ 0.01 ). The serum NSE, hs-CRP levels in HIE group of the severe acute stage were significantly higher than those of the mild and light acute stage (P＜0.01 ). The more severe disease, the more higher NSE, hs-CRP. Conclusion The serum NSE, hs-CRP reflect the brain neuronal damage or necrosis of the objective indicators that could be used as early objective indicators to judge the pathogenetic condition and prognosis of HIE.