The Observation of Curative Effect for Telsartan In Curing Essential Hypertension
10.3760/cma.j.issn.1008-6706.2010.14.027
- VernacularTitle:替米沙坦治疗原发性高血压的疗效观察
- Author:
Bairu XIE
;
Xi ZHOU
;
Zhenzhi ZHANG
- Publication Type:Journal Article
- Keywords:
Telsartan;
Valsartan;
Essential Hypertension;
Curative Effect;
Safety
- From:
Chinese Journal of Primary Medicine and Pharmacy
2010;17(14):1925-1926
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the curative effect and safety issues of Telsartan(Micardis) and Valsartan (Diovan) Capsule in curing light and to moderate essential hypertension patients. Methods The 126 light or moderate essential hypertension patients were divided into two groups randonly:63 patients in Micardis group(80mg qd)and 63 patients in Diovan group(160mg qd). The courses of treatment of each group were 8 weeks. The medicine was taken by patients after breakfast everyday. Data of blood pressure, heart rhythm, blood and urine routine test, hepatic and renal function, blood biochemistry test, ECG and side effects was recorded everyday before and after the treatment. Results After 8 weeks treatment, the average SBP of blood pressure was reduced from ( 156.3 ± 13.3 ) mm Hg to(128.6 ± 10.9) mm Hg(Micardis group)and (129.3 ± 11.3) mm Hg(Diovan group). The average DBP was reduced from(98.3±11.6) mm Hg to(80.3±7.1) mm Hg(Micardis group)and(80.6 ±7.3) mm Hg(Diovan group). The blood pressure of both group had notable decreasing after taking medicine(P ＜ 0.01). The total effective rates were 79.36% and 73.02%. In the same term,the curative effect of both group have significant difference(P＜0.05). In Micardis group,total Cholesterol(TC) level reduced from(5.6 ± 1.2) mmol/L to( 4.9 ± 1.1 ) mmol/L; Triglyceride (TG) level reduced from (2.38 ± 0.31) mmol/L to (2.23 ± 0.33) mmoL/L; Low Density Lipoprotein Cholesterol(LDL-C) level reduced from( 3.26 ± 0.38 ) mmol/L to( 2.89 ± 0.46 ) mmol/L; High Density Lipoprotein Cholesterol (HDL-C) level increased from ( 1.3 ± 0.6 ) mmol/L to ( 1.5 ± 0.3 ) mmol/L. As comparison, in the Diovan group only the TC level reduced from (5.6 ± 1.2) mmol/L to(5.2 ± 1.3) mmol/L. Both groups did not have significant adverse reactions. Conclusion As the Angiotensin Ⅱ Receptor Antagonist ( ARA), both the Telsartan and Valsartan Capsule were effective medicines in curing light and moderate essential hypertension patients. These two medicines which were reliable and safety,had good tolerance and few side effects. However,Telsartan had better effects than Diovan in reducing blood pressure and triglyceride on light or moderate essential hypertension patients. Also, Telsartan had longer half-life period(18-24h) and lower price.
