Association of polymorphisms of -139 and -336 nucleotides in DC-SIGN promoter region with HIV infection
10.3760/cma.j.issn.1674-2397.2010.04.004
- VernacularTitle:DC-SIGN启动子区-139和-336位点多态性与HIV感染的关系
- Author:
Qinguang LI
;
Lijun XU
;
Qiyun ZHANG
;
Fan HUANG
;
Huicong CHEN
;
Ronghua CHEN
- Publication Type:Journal Article
- Keywords:
Human immunodeficiency virus;
Dentritic cell specific intercellular adhesion molecule-3-grabbing nonintegrin;
Susceptibility;
Infection;
Lymphocyte
- From:
Chinese Journal of Clinical Infectious Diseases
2010;03(4):204-208
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the polymorphisms of-139 and -336 nucleotides in dendritic cells specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN) promoter region in context of HIV susceptibility, infection routines and HIV/AIDS progress. Methods Polymorphisms of -139 and -336 nucleotides in DC-SIGN were examined in 160 HIV-positive subjects and 178 healthy controls;the Spearman test was performed to analyze their associations with HIV infection status. Results In 160 HIV-positive subjects, there were 92 (57.5%) with-139C, 68 (42.5%) with-139T, 29 (18.1%) with-336C and 131 (81.9%) with -336T. The frequencies of -139T/C and -336T/C in HIV-positive subjects were similar to those in the healthy controls (χ2 =0. 121 and 1. 754, P ＞0.05 ). No differences were found in the distribution of -139T/C or -336T/C in HIV-positive subjects infected via sex intercourse or intravenous drug (χ2 =0. 435 and 0. 103, P ＞ 0. 05 ). -139C was usually companied with -336C ( r = 0. 359, P ＜ 0.01 ).-139T (27.9%) were more frequently presented in patients with CD4 +T cells ≤50 cells/μL than -139C( 23.0%, χ2 = 4.055, P ＜ 0.05 ). -139T/C and -336T/C were not related to HIV RNA levels ( t = - 0. 643and - 1. 637, P ＞ 0.05). Conclusions Genotype -139C in DC-SIGN promoter region usually coexist with -336C. Polymorphisms of -139 and -336 are not related to HIV susceptibilities or HIV infection routes.-139T genotype may be related to serious depletion on CD4 + T cells.
