Combined haemostatic percutaneous injection therapy for renal trauma under guidance of contrast-enhanced ultrasonography
10.3760/cma.j.issn.1001-8050.2010.08.024
- VernacularTitle:超声造影引导下联合止血剂注射治疗肾挫裂伤的实验研究
- Author:
Zhiyan LI
;
Jie TANG
;
Yukun LUO
;
Faqin Lü
;
Ziyu JIAO
;
Qing SONG
;
Tengfei YU
- Publication Type:Journal Article
- Keywords:
Kidney;
Contusions;
Surgical procedure,minimally invasive;
Hemostasis;
Contrast-enhanced,ultrasonography
- From:
Chinese Journal of Trauma
2010;26(8):739-742
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study feasibility of combined haemostatic percutaneous injection therapy guided by contrast-enhanced ultrasonography (CEUS) in treatment of renal injuries. Methods Eighteen New Zealand rabbits were inflicted with kidney injury imitating grades Ⅲ-Ⅳ blunt injuries. The animals were randomly and equally divided into three groups, Group A ( treated with hemocoagulase),Group B ( treated with hemocoagulase and Alpha-cyanoacrylate) and Group C ( control group, given normal saline). The hemostatic time, hemostatic effect, and perirenal hematoma were observed. Results A perirenal hematoma was observed one hour after treatment. The perirenal fluid thickness was (0.200 ±0.012) cm in Group A, (0.050 ±0.002) cm in Group B and (0.400 ±0.009) cm in Group C, with statistical significance between two test groups and Group C (P ＜ 0.05 ). At days 7 and 14 following treatment, lesion length and cross section was ( 1. 107 ±0. 143) cm and (0.433 ±0. 163) cm in Group A, (0.567 ±0.082) cm and (0. 160 ±0. 078) cm in Group B, and (0.980 ±0. 203) cm and (0.686 ± 0. 157) cm in Group C. There was statistical significance between the test groups (Groups A and B) and Group C (P＜0. 01) at day 14. The lesion size in Group A was lager than that in Group B (P ＜ 0.01 ). One month after treatment, a slight nephrohydrosis occurred in Group B. Conclusions Either injection of simple hemocoagulase or combined use of hemocoagulase and Alpha-cyanoacrylate guided by CEUS can attain positive hemostatic effect, but the latter one is more rapid and reliable.
