Effects of monosialoganglioside on adrenal medulla grafts in the rat model of Parkinson's disease
- VernacularTitle:单涎酸神经节苷脂对Parkinson病大鼠纹状体内肾上腺髓质移植物的影响
- Author:
Yi QING
;
Jiazheng SU
;
Guofeng ZHANG
- Publication Type:Journal Article
- Keywords:
Monosialoganglioside;
Adrenal medulla;
Transplantation
- From:
Chinese Journal of Organ Transplantation
1997;18(1):28-30
- CountryChina
- Language:Chinese
-
Abstract:
Rat's adrenal medulla(AT group)or adrenal medulla soaked with monosialogan-glioside(AGT group)were transplanted into the head of striatum of rat model of Parkinsonism.Apomorphine induced greater improverment in rotational behavior in AGT group than in AT group with significant difference.Immunocytochemical staining with Chromagranin A showed that a lot of positively stained cells were distributed in the graft area and some cells developed process in AGT group. Our results showed that the monosialoganglioside had effects of increasing the survival of chromaffin cells and inducing the cells to develop processes.
