Experimental study on intrathymic islet transplantation
- VernacularTitle:胸腺内胰岛移植的实验研究
- Author:
Guodong WANG
;
Guihua CHEN
- Publication Type:Journal Article
- Keywords:
Thymus gland;
Islands of Langerhans/transplantation;
Immune tolerance
- From:
Chinese Journal of Organ Transplantation
1999;20(1):22-24
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of intrathymic islet transplantation or renal subcapsule islet transplantation on the graft survival.Methods C57BL/6 mice were used as recipients and BALB/c as donors The recipients receiving intrathymic or renal subcapsule islet transplantation were divided into simple transplantation groups and the group intraperitoneally receiving rabbit antithymocyte serum(ATS) at the time of islet transplantation.Results The median survival time (MST) of simple intrathymic allografts were 19.5 days,longer than that of allografts implanted beneath the renal capsule.Administration of ATS at the time of islet transplantation delayed rejection of islets transplanted to the renal subcapsute(MST,43.0 days),and intrathymic allografts were superior(MST,93.8 days).Six of 8 intrathymic grafts with administration of ATS survived permanently.especially a state of donor-specific unresponsiveness was induced.Conclusion The thymus may be an immunoprivileged site for islet transplantation and may play an important role during the induction of immune tolerance.
