Experimental study on the rat cardiac xenotransplantation
- VernacularTitle:大鼠异种心脏移植的实验研究
- Author:
Guihua CHEN
- Publication Type:Journal Article
- Keywords:
Plasmapheresis;
Cyclophosphamide;
Cardiac xenograft
- From:
Chinese Journal of Organ Transplantation
1996;17(4):158-159
- CountryChina
- Language:Chinese
-
Abstract:
In guinea pig to rat cardiac xenotransplantation model,plasmapheresis,splenectomy and cyclophosphamide were used to reduce the content of the plasmatic natural antibodies.The survival time of the grafts was observed.It was found that plasmapheresis could lead to a dramatic drop of the natural antibodies in the plasma.Plasma IgM and IgG was significantly reduced to 167 mg/dl and 693.3mg/dl after plasmapheresis from 936.0mg/dl and 2 424.3mg/dl before plasmapheresis.Survival time of the control group was 13.2 min,while survival time of the plasmapheresis group was 537.0 min.The combined use of plasmapheresis,splenectomy and cyclophos-phamide could further prolong the survival time of the xenografts(760.0min).
