A clinical study on the efficacy of oral minirin in transsphenoidal surgery patients with central diabetes insipidus
10.3760/cma.j.issn.1008-6315.2010.06.027
- VernacularTitle:弥凝治疗经蝶垂体腺瘤术后中枢性尿崩症的临床研究
- Author:
Qi DONG
;
Ran YI
;
Fengping HAN
- Publication Type:Journal Article
- Keywords:
Minirin;
Central diabetes insipidus;
Pituitary adenoma;
Transsphenoidal surgery
- From:
Clinical Medicine of China
2010;26(6):631-632
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of oral minirin in postoperative transsphenoidal surgery patients with central diabetes insipidus. Methods The changes in the urine volume and osomlality after two weeks of minirin medication (0. lmg, 3 times each day) were observed in 34 patients with central diabetes insipidus underwent transsphenoidal surgery. Results After two weeks of minirin therapy,the average daily urine volume decreased from 7985.40 ±410. 36 ml to 2277. 87 ± 328. 94 ml,and the average plasmas osmolarity increased from 301. 68 ± 3. 59 ml/d to 313. 26 ±4. 87 mOsm/ kg. No adverse reaction was observed during the therapy. Conclusions Minirin is effective and safe in the therapy of postoperative transsphenoidal surgery patients with central diabetes insipidus.
