Diagnostic value of common inflammatory markers in patients with infectious diseases
10.3760/cma.j.issn.1000-6680.2010.08.009
- VernacularTitle:常用炎性指标对感染性疾病的诊断价值
- Author:
Liang HONG
;
Wenfei HE
;
Jiguang DING
;
Jibao PAN
;
Qingfeng SUN
;
Rongquan FU
;
Jinguo WU
;
Hongying SHI
- Publication Type:Journal Article
- Keywords:
Calcitonin;
Protein precursors;
Sepsis;
ROC curve
- From:
Chinese Journal of Infectious Diseases
2010;28(8):488-491
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the diagnostic value of common inflammatory markers in patients with infectious diseases. Methods One hundred sepsis patients, 100 viral infection patients,100 pulmonary tuberculosis patients and 100 gonorrhea patients were analyzed retrospectively. The contents of procalcitonin (PCT), C-reactive protein (CRP), haptoglobin (HP), ceruloplasmin (CER), α1-acid glycoprotein (α1-AAG), α1-antitrypsin (α1-AAT), white blood cell count (WBC) and erythrocyte sedimetation rate (ESR) were measured. The receiver operating characteristic curve (ROC curve), sensitivity, specificity, positive predictive value, negative predictive value, Youden's index,positive and negative likelihood ratios and total coincidence rate were calculated respectively. Results The area under the ROC curve, sensitivity, specificity, Youden's index and positive likelihood ratios,positive predictive value and total coincidence rate of PCT in sepsis patients were 0. 895, 0.84, 0.92,0.76, 10.50, 0.91 and 0.88, respectively, which were superior to CRP, HP, CER, α1-AAG, α1-AAT, WBC and ESR. Conclusions PCT is a better inflammatory reactive parameter than other parameters currently applied in practice and may serve as a rapid and sensitive test in the early stage of severe bacterial infections.
