Oxygen free radical formation during hyperacute rejection in guinea pig to rat xenotransplantation
- VernacularTitle:豚鼠对大鼠异种心脏移植超急性排斥时氧自由基变化
- Author:
Tao WANG
;
Suisheng XIA
- Publication Type:Journal Article
- Keywords:
Xenotransplantation;
Hyperacute rejection;
Oxygen free radical
- From:
Chinese Journal of Organ Transplantation
1996;17(2):58-59
- CountryChina
- Language:Chinese
-
Abstract:
In order to determine the relationship between hyperacute xenograft rejection and oxygen free radical(OFR)formation,in the model of guinea pig to SD rat cardiac xenotransplantation guinea pig heart specimens were obtained at harvesting,after stored in Ringer's lactate solution(4℃)for 1 hour,and at 60 min after transplantation to assess histological changes and OFR production by light microscopy,electromicroscopy and luminol-enhanced chemiluminescence (LC).OFR formation increased significantlly in hyperacute rejection.These findings suggests that OFR may play important role in the pathogenesis of discordant xenograft rejection.
