The disorder of bleeding and coagulation in the peritoneal dialysis patients
- VernacularTitle:慢性肾功能衰竭腹膜透析患者的出凝血紊乱
- Author:
Ying CHEN
;
Qinjun XU
- Publication Type:Journal Article
- Keywords:
Peritoneal dialysis;
Kidney failure,chronic;
Thrombin;
Fibrinolysis;
Platelet
- From:
Chinese Journal of Organ Transplantation
1997;18(1):16-18
- CountryChina
- Language:Chinese
-
Abstract:
Plasma level of KPTT,factor Ⅷ coagulant activity,factor Ⅷ-related antigen,fib-rinogen,antithrombin Ⅲ activity,antithrombin Ⅲ antigen,tissue-plasminogen activator activity (t-PA:C),plasminogen activator inhibitor activity(PAI:C),PAI:C/t-PA:C,plasmin activity (PLm:C),D-dimer and plasma platelet α granule membrane protein were ditermined in 26 patients treated by long-term peritoneal dialysis(PD group),17 patients with chronic renal failure under-going conservative therapy(CRF group),36 patients on maintenance hemodialysis(HD group) and 20 age & sex-matched normal controls(NC group).The results showed:1.PD group had hypercoagulable state than NC group.The prothrombotic state in PD patients was most severe in contrast with CRF patients and HD patients.2.When PD group was compared with NC group,PLm:C showed no significant differences,but they had secondary fibrinolysis following enhanced coagulation.Moreover,PLm:C in PD group was significantly depressed as compared with in CRF group.3.the activated platelets in the PD patients were significantly elevated as compared with in the normal controls.
