Clinical characteristics and high risk factors of diabetes mellitus following renal transplantation
- VernacularTitle:肾移植术后糖尿病的临床特性及高危因素
- Author:
Yawang TANG
;
Yuhai ZHANG
;
Baoxiang JIA
- Publication Type:Journal Article
- Keywords:
Kidney/transplantation;
Diabetes mellitus
- From:
Chinese Journal of Organ Transplantation
1999;20(2):95-96
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical characteristics and risk factors for postrenal transplant diabetes mellitus (PTDM). Methods 512 consecutive kidney recipients were included in this study from 1994.1 to 1997. 5.Biochemical data, body weight changes, drug history, genetic markers such as HLA phenotypes, anti-virus antibodies were studied in these patients.Results The mean age and the dose of hormone used 6 months after operation in the diabetes mellitus group were older and higher than in the nondiabetes groups respectively. PTDM often occurred half a year following renal transplantation. And no patients with PTDM were obese. Most PTDM patients had a higher blood glucose level, but few of them had ketoacidosis. The occurrence of HLA-B15 and the positive rate of anti-gland virus antibody were significantly higher in PTDM group. Conclusion Both genetic factors such as HLA type antigens and environmental factors such as the amounts of steroid and cyclosporine A used, infections of some kinds of viruses, and also stress during transplantation may play an important role in the causes of PTDM.
