β-Catenin,β-Trcp and CRD-BP in colorectal cancer
10.3760/cma.j.issn.1673-422X.2010.08.018
- VernacularTitle:β-Catenin、β-Trcp 及CRD-BP与结直肠癌
- Author:
Kun LI
;
Xianqin HOU
;
Xiyu WANG
- Publication Type:Journal Article
- Keywords:
Colorectal neoplasms;
Signal transduction;
β-Catenin
- From:
Journal of International Oncology
2010;37(8):612-614
- CountryChina
- Language:Chinese
-
Abstract:
Wnt/β-catenin signaling pathway plays an important role in the initiation and progression of colorectal cancer. The key to its carcinogenicity is related to the inhibition of β-catenin degradation, and the subsequent cytoplasmic accumulation and nuclear translocation of β-catenin, which activates the transcription of downstream target genes such as coding region instability determinant-binding protein (CRD-BP). In cancercells ,the expression of CRD-BP mediates the stabilization of β-Trcp, which in normal cells regulates the degradation of β-catenin. The activation of Wnt/β-catenin signaling pathway, overexpression of β-catenin and CRDBP, and the upregulation of β-Trcp by CRD-BP play important roles in the initiation, progression, and metastasis of colorectal cancer.
