Comparison of sedative effects of different fractions from patrinia scabiosaefolia fisch in mice
10.3760/cma.j.issn.1008-1372.2010.08.004
- VernacularTitle:黄花败酱不同部位对小鼠镇静催眠效果的比较
- Author:
Xiangdong PENG
;
Xuefeng WANG
- Publication Type:Journal Article
- Keywords:
PATRINIA SCABIOSAEFOLIA/CH/PD;
Conscious sedation;
Hypnosis
- From:
Journal of Chinese Physician
2010;12(8):1022-1024
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the sedative effects of different fractions of patrinia scabiosaefolia fisch. in mice and provide some valuable information for isolating components with sedative effect.Methods Petroleum, acetic ether and n-butanol fraction was isolated from the patrinia scabiosaefolia fisch.. The sedative effects were determined with locomotor activity assay, hole board test and sodium thiopental-induced sleeping time assay, and it was compared with the effects of total 70% ethanol extract. Results N-butanol fraction showed better sedative effect compared with others, and it was in a dose-dependent manner. Conclusion The results showed that the main active principles of patrinia scabiosaefolia fisch. were the n-butanol fraction, and the promising active chemical might be obtained from this fraction.
