Apolipoprotein E gene polymorphism in patients with cerebral infarction in Dali Bai populations in Yunnan province
10.3760/cma.j.issn.1673-4165.2010.07.002
- VernacularTitle:云南大理白族脑梗死患者载脂蛋白E基因多态性研究
- Author:
Hong XU
;
Li NIE
;
Qihong YUAN
;
Lühua CHANG
;
Zhi NIE
;
Liping WANG
- Publication Type:Journal Article
- From:
International Journal of Cerebrovascular Diseases
2010;18(7):488-493
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between apolipoprotein E (ApoE)polymorphisms and cerebral infarction in Dali Bai populations in Yunnan province.Methods A total of 40 Dali Bai patients with cerebral infarction (female.23,male 17) and 43 Dali Bai normal controls (female 18,male 25) were included in the study.Polymerase chain reactionrestriction fragment length polymorphism (PCR-RFLP) analysis was used to detect APoE genotype,meanwhile the lipid levels were detected,and finally,ApoE gene sequencing was conducted.The correlation between the APoE gene polymorphism and the types of cerebral infarction were further studied.Results The frequencies of genotype ε3/ε4 (22.5% vs.4.7%,P ＜0.05) and ε4 (12.5% vs.3.5%,P ＜0.05) in the Dali Bai cerebral infarction group were significantly higher than those in Dali Bai normal control group,and the frequencies of genotype
