Dickkopf-1 and tumor
10.3760/cma.j.issn.1673-422X.2010.08.002
- VernacularTitle:Dickkopf-1与肿瘤
- Author:
Jiankun ZHU
- Publication Type:Journal Article
- Keywords:
Neoplasms;
Wnt proteins;
Dickkopf-1
- From:
Journal of International Oncology
2010;37(8):565-567
- CountryChina
- Language:Chinese
-
Abstract:
Dickkopf-1 (DKK-1) plays an important role in the initiation and progression of many human cancers. It can induce apoptosis of a wide variety of tumor cells in vivo through both the canonical Wnt/β-catenin signal transduction pathway and the non-canonical Wnt signal transduction pathway. In addition, DKK-1 can modulate bone metastasis and promote the invasion and infiltration of some tumor cells.
