Toll-like receptors and tumor microenvironment
10.3760/cma.j.issn.1673-422X.2010.08.003
- VernacularTitle:Toll样受体与肿瘤微环境
- Author:
Junli DING
;
Fang HUANG
- Publication Type:Journal Article
- Keywords:
Toll-like receptors;
Neoplastic processes;
Neoplasm invasiveness;
Neoplasm metastasis
- From:
Journal of International Oncology
2010;37(8):567-569
- CountryChina
- Language:Chinese
-
Abstract:
Toll-like receptor (TLR) plays a crucial role in innate immune response and the subsequent induction of adaptive immunity. TLR is expressed on immune cells as well as epithelial cells and tumor cells. When endogenous and exogenous ligands bind with TLR, TLR signaling pathways are activated and a large number of inflammatory cytokines are released, creating an inflammatory microenvironment and leading to tumor formation, invasion and metastasis.
