Expressions of CK20, S100A7 and substance P in different stages of psoriatic lesions and their relationship
10.3760/cma.j.issn.0412-4030.2010.09.003
- VernacularTitle:不同病期银屑病皮损组织CK20、S100A7、SP的表达及其相关性
- Author:
Taihua LIU
;
Defang LIU
;
Yihua CHEN
;
Xinhong WANG
;
Xiaojun WANG
;
Jun WANG
;
Yifu DENG
;
Chen LUO
- Publication Type:Journal Article
- Keywords:
Psoriasis;
Merkel cells;
Keratin-20
- From:
Chinese Journal of Dermatology
2010;43(9):606-609
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expressions of CK20, S100A7 and substance P (SP) in different stages of psoriatic lesions and their relationship. Methods A total of 19 patients, who had received irregular treatment for psoriasis and had both progressive and healed psoriatic lesions, were enrolled in this study. Skin tissue specimens were obtained from perilesional normal skin, progressive lesions and healed lesions of these patients and subjected to immunohistochemical analysis of expressions of CK20, S100A7 and SP. Results The relative expression level (absorbance value obtained from immunohistochemical analysis) was 7683.80 ± 6134.55,18305.04 ± 13171.30, 7257.53 ± 4417.75 for CK20, 8789.05 ± 6240.91, 18058.01 ± 16537.18, 9295.65 ±9310.02 for S100A7, 3242.51 ± 3775.41, 9364.98 ± 7596.64, 2910.85 ± 3349.46 for SP, respectively, in normal skin, progressive lesions and healed psoriatic lesions. A significant increase was observed in the expressions of CK20, S100A7 and SP in progressive lesions compared with normal skin and healed lesions, whereas no statistical difference was noted in those between normal skin and healed lesions (P ＞ 0.05 ). The expression of CK20 was positively correlated with that of S100A7 and SP (r = 0.779, 0.876, both P ＜ 0.05 ). Conclusion The pathogenesis of psoriasis seems to be associated with the changes in the number of Merkel cells.
