Expressions of Toll-like receptor 2 and 4 in peripheral blood monouclear cells of patients with leprosy

VernacularTitle:Toll样受体2、4在麻风患者外周血单一核细胞中的表达
Author: Li LUO ; Yuan LIU ; Xinjiang ZHANG ; Dongping LU ; Qingbo ZHANG ; Baoren WANG ; Fangming LIU
Publication Type:Journal Article
Keywords: Leprosy; Toll-like receptor 2; Toll-like receptor 4; Monocytes
From: Chinese Journal of Dermatology 2010;43(9):623-625
CountryChina
Language:Chinese
Abstract: Objective To study the mRNA expressions of Toll-like receptor (TLR) 2 and 4 in peripheral blood mononuclear cells (PBMCs) of patients with leprosy. Methods SYBR Green fluorescence quantitative RT-PCR was conducted to detect the mRNA expressions of TLR2 and 4 in PBMCs from 30 patients with cured leprosy, 30 patients with active leprosy and 30 normal human controls. Results The expression of TLR2 mRNA in patients with active leprosy was significantly higher than that in those with cured leprosy and in controls (both P ＜ 0.01 ), but there was no significant difference between the latter two groups (P ＞ 0.05). The expression of TLR4 mRNA was of no significant difference between patients with active leprosy and those with cured leprosy orthe controls (both P＞ 0.05). Conclusion The expression of TLR2 mRNA is decreased in PBMCs from leprosy patients, suggesting that TLR2 may be a specific recognition receptor in patients with leprosy.