Polymorphisms of the high-affinity receptor for IgE alpha-chain (FcεRIα) gene in patients with atopic dermatitis

VernacularTitle:特应性皮炎患者IgE受体FcεRIα基因多态性研究
Author: Hong DANG ; Juan ZHOU ; Zuolin YING ; Weimin SHI ; Li LI
Publication Type:Journal Article
Keywords: Dermatitis atopic; Genes FcεRI; Polymorphism,single nucleotide
From: Chinese Journal of Dermatology 2010;43(9):626-628
CountryChina
Language:Chinese
Abstract: Objective To assess the relationship between single nucleotide polymorphisms of FcεRIαgene and atopic dermatitis. Methods Genomic DNA samples were extracted from peripheral blood of 97 patients with atopic dermatitis and 283 normal human controls. The polymorphism at the distal promoter region of FcεRIα gene was determined by PCR-ligase detection reaction assay followed by gene sequencing. Results A G/T polymorphism was observed at position rs61828219 in the promoter region of FcεRIα gene, while all the tested individuals were homozygous for T/T at position rs12135235 and A/A at position rs36233780 in the promoter region of FcεRIα gene. The mutation frequency at position rs61828219 was 1.04% and 2.17% in patients with AD and normal human controls, respectively (both P ＞ 0.05). Conclusions In the Chinese Han population, there is a G/T polymorphism at position rs61828219 in FcεRIα gene promoter region, which is unlikely related to the development of AD; however, no polymorphism is detected at position rs12135235 or rs36233780.