The clinical value of bone marrow biopsy in diagnosing aggressive NK cell leukaemia

VernacularTitle:骨髓病理检查对侵袭性NK细胞白血病的诊断价值
Author: Weihua YIN ; Hongyu ZHANG ; Ya MA ; Guanglin CAI ; Guangyin YU ; Yaoli CHEN
Publication Type:Journal Article
Keywords: Leukemia,lymphocytic; Bone marrow examination; Immunohistochemistry
From: Chinese Journal of Primary Medicine and Pharmacy 2010;17(10):1313-1314
CountryChina
Language:Chinese
Abstract: Objective To explore the value of bone marrow biopsy ( BMB) in early diagnosis of aggressive NK cell leukaemia( ANKL). Methods The clinical data of ten cases with ANKL were retrospectively analyzed,morphology, immunophenotype and hybridization in situ of bone marrow were analyzed. Results In all cases, BMB showed hypercellular, with 4 cases markedly hypercellular. Atypical neoplastic cells demonstrated focal and fascicle growth pattern and were composed of median-sized cells with a few cytoplasm, slightly irregular nuclei, fine chromatin, indistinct nucleoli and some mitotic counting. Characteristic histocytes with haemophagocytosis were observed in the bone marrow slides. The neoplastic cells were positive for CD2、CD3e、CD7、CD56、TIA-1. EBER was found positive in all cases. Conclusion Bone marrow biopsy and immunochemistry were essential and reliable diagnostic tool in early diagnosis of ANKL.