Small molecule inhibitors of Bcl-2 proteins:research progress
10.3760/cma.j.issn.1673-422X.2010.08.007
- VernacularTitle:Bcl-2蛋白小分子抑制剂的研究进展
- Author:
Zujin CHEN
;
Bin ZHANG
- Publication Type:Journal Article
- Keywords:
Apoptosis regulatory proteins;
Apoptosis;
Neoplasms;
Inhibitor
- From:
Journal of International Oncology
2010;37(8):579-581
- CountryChina
- Language:Chinese
-
Abstract:
Small molecule inhibitors of Bcl-2 are a novel class of anticancer drugs that target anti-apoptotic proteins. In recent years,small molecule inhibitors such as ABT-737 ,ABT-263, gossypol, apogossypol,TW-37,obatoclax, HAl4-1 have attracted much reseach attention. Preclinical trials have shown that the inhibitors have cancer killing effect on some tumors when used alone and exhibit striking synergistic effect when combined with radiotherapy and/or chemotherapy.
