EGFR-targeted therapy in gastric cancer
10.3760/cma.j.issn.1673-422X.2010.08.017
- VernacularTitle:抗EGFR靶向治疗胃癌
- Author:
Liang WANG
- Publication Type:Journal Article
- Keywords:
Epidermal growth factor;
Stomach neoplasms;
Drug therapy;
Clinical trials
- From:
Journal of International Oncology
2010;37(8):609-611
- CountryChina
- Language:Chinese
-
Abstract:
Epidermal growth factor receptor(EGFR) family plays an important role in the development of gastric cancer. EGFR-targeted therapeutic agents include extracellular monoclonal antibodies and intracellular tyrosine kinase inhibitors. Many new agents such as trastuzumab, cetuximab, panitumumab and lapatinib, have been tested in randomized phase Ⅲ clinical trials. Results from ToGA trial may shed some light on the treatment of advanced gastric cancer.
