Secreted rotein acidicand rich in cysteine and cancer research
10.3760/cma.j.issn.1673-422X.2010.07.008
- VernacularTitle:富含半胱氨酸的酸性分泌蛋白与恶性肿瘤
- Author:
Lu ZHU
- Publication Type:Journal Article
- Keywords:
Osteonectin;
Methylation;
Apoptosis;
Neoplasm metastasis
- From:
Journal of International Oncology
2010;37(7):504-507
- CountryChina
- Language:Chinese
-
Abstract:
Secreted rotein acidicand rich in cysteine (SPARC), belonging to a family of matricellular proteins, is a multifunctional calcium-binding glycoprotein. In tumors, it functions as de-adhesion, antiproliferation, and regulation of extracellular matrix (ECM) interactions. But in different tumors,SPARC performances different biological effects, as in melanoma, breast cancer, esophageal cancer, etc, SPARC is associated with a highly aggressive tumor phenotype, while in ovarian cancer, cervical cancer, non-small cell lung cancer,SPARC may function as a tumor suppressor.
