Gamma synuclein and drug resistance in cancer
10.3760/cma.j.issn.1673-422X.2010.07.009
- VernacularTitle:γ突触核蛋白与肿瘤耐药
- Author:
Junyi CHEN
;
Chuanliang XU
- Publication Type:Journal Article
- Keywords:
Synucleins;
Neoplasms;
Drug therapy
- From:
Journal of International Oncology
2010;37(7):507-510
- CountryChina
- Language:Chinese
-
Abstract:
Synuclein-γ (SNCG) is overexpressed in many advanced stages cancers, including breast cancer, ovarian cancer, prostate cancer, lung cancer, liver cancer, esophagus cancer, and colon cancer.SNCG stimulates the proliferation, metastasis, and drug resistance of tumor cells, through interacting with BubR1 and damage mitotic checkpoint. A peptic ANK targeted at SNCG can inhibit activity of SNCG and may be developed as an adjuvant therapy.
