Vasculogenic mimicry and hepatocellular carcinoma
10.3760/cma.j.issn.1673-422X.2010.07.018
- VernacularTitle:血管生成拟态与肝癌研究进展
- Author:
Wenbin LIU
- Publication Type:Journal Article
- Keywords:
Liver neoplasms;
Extracellular matrix;
Vasculogenic mimicry
- From:
Journal of International Oncology
2010;37(7):536-539
- CountryChina
- Language:Chinese
-
Abstract:
The term vasculogenic mimicry describes the formation of fluid-conducting channels by highly invasive and genetically dysregulated tumor cells. The molecular mechanisms of vasculogenic mimicry may be associated with phenotypically interconversion, tumor-extracellular matrix interactions and abnormality in signal pathway of tumor cells. It is recently discovered that in hepatocellular carcinoma vasculogenic mimicry may be associated with the invasive and metastatic potential of tumor cells, as well as poor clinical outcome. This article reviews the present research progression of vasculogenic mimicry in hepatocellular carcinoma.
