Expression and significance of endothelin-1 in mucosa of urothelial transitional cell carcinoma
10.3760/cma.j.issn.1673-422X.2010.07.025
- VernacularTitle:尿路移行细胞癌患者黏膜组织中内皮素-1的表达及意义
- Author:
Xingming LIU
;
Wenfa YANG
;
Hui WANG
;
Bin YANG
;
Hao CHEN
;
Daoyuan LU
- Publication Type:Journal Article
- Keywords:
Endothelins;
Carcinoma,transitional cell;
Immunohistochemistry
- From:
Journal of International Oncology
2010;37(7):557-558
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and significance of endothelin-1 ET-1 in urothelial transitional cell carcinoma. Methods Immunohistochemistry was applied to detect ET-1 expression in 30 cases of urothelial transitional cell carcinoma and 20 cases of normal urothelial transitional cell samples, the results were analyzed in combination with clinical data. Results ET-1 expression in urothelial transitional cell carcinoma was 40.5%, which was significantly higher than that in normal urothelial transitional cell samples(P ＜0.05). ET-1 expression was correlated with grade and stage of urothelial transitional cell carcinoma (P ＜0.05). Conclusion The over expression of ET-1 in urothelial transitional cell carcinoma tissues correlates closely with cancer genesis progression and invasiveness, suggesting that ET-1 might be a biomarker and as a therapeutic target in human urothelial transitional cell carcinoma.
