Advancement of Reovirus-based therapy for cancer
10.3760/cma.j.issn.1673-422X.2010.07.011
- VernacularTitle:呼肠孤病毒治疗肿瘤研究进展
- Author:
Jinye HUANG
;
Lijun MAO
;
Jiacun CHEN
- Publication Type:Journal Article
- Keywords:
Reoviridae;
Oncolytic viruses;
Neoplasmas
- From:
Journal of International Oncology
2010;37(7):514-517
- CountryChina
- Language:Chinese
-
Abstract:
Reovirus,a kind of oncolytic viruses, is seldom pathogenic, but is selectively able to replicate in cancer cells through activation of Ras signaling. Pre-clinical studies have demonstrated that treatment with reovirus is associated with significant anticancer activity across a range of tumor types. Further clinical evaluation of reovirus therapy has shown that it is well tolerated when administered locally or systemically. Encouraging anticancer efficacy has been observed with single-agent treatment and in combination with chemotherapy and radiotherapy. High safety and promising efficacy of reovirus has raised hopes that it will become a new anticancqt agent.
