Protective effect of α-lipoic acid on mitochondrial energy metabolism of liver in the rat with obstructive jaundice
10.3760/cma.j.issn.1673-4203.2010.09.005
- VernacularTitle:α-硫辛酸对阻塞性黄疸大鼠肝细胞线粒体内能量代谢保护作用及机制
- Author:
Xiaoguang GONG
;
Yunfu LV
;
Jie YUE
;
Qingan QIU
- Publication Type:Journal Article
- Keywords:
Obstructive jaundice;
α-lipoic acid;
Energy metabolism;
Malondialdehyde;
Superoxidedismutase
- From:
International Journal of Surgery
2010;37(9):588-591
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of α-lipoic acid on mitochondrial energy metabolism of liver in the rat with obstructive jaundice. Methods Seventy-two male SD rats were randomly divided into groups of sham operation and bile duct-ligation + normal soldium( BDL + NS) and bileduct-ligation + α-lipoic acid( BDL + LA). Malondialdehyde(MDA) , superoxide dismutase(SOD) and ATP, ADP, AMP in rat liver's mitochondrion were examined on days 7,14,21 after operation. Results MDA contents, ADP contents and AMP contents of liver' s mitochondrion were significantly increased at each time point in BDL + NS-group,while SOD contents and ATP contents of liver' s mitochondrion decreased remarkably on the 7th, 14th days; MDA content of liver' s mitochondrion in BDL + LA group was more lower than that in BDL + NS group (P ＜ 0. 01 )on the 21st day; MDA content was further increased in BDL + NS group and in BDL + LA group but there was no difference in their comparisons. On the 7th, 14th days, SOD contents and ATP contents in BDL + LA group were significantly higher than that in BDL + NS group( 7th days,P ＜ 0. 01; 14th days,P ＜ 0.05 ), On the 21 st day SOD contents in BDL + NS group had no difference with that in BDL + LA group (P ＞ 0. 05). Conclusions LA has a protective effect on energy metabolism of liver' s mitochondrion in the initial ,metaphase stage of obstructive jaundice.
