Sulfotransferase and breast cancer
10.3760/cma.j.issn.1673-422X.2010.08.011
- VernacularTitle:硫酸基转移酶与乳腺癌
- Author:
Yiwei JIANG
;
Liheng ZHOU
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Estrogens;
Polymorphism,single nucleotide
- From:
Journal of International Oncology
2010;37(8):591-593
- CountryChina
- Language:Chinese
-
Abstract:
Sulfotransferase (SULT) enzymes play important roles in the biosynthesis of estrogen.These enzymes catalyze the sulfation of estrogens to form biologically inactive molecules. Several studies have shown that Arg213His polymorphism in SULT1A1 gene may be a risk factor for breast cancer. In addition, a low mRNA expression of SULT has been significantly associated with reduced recurrence and improved overall survival in patients with estrogen receptor (ER)-positive tumors. Furthermore, SULT may be a crucial factor in the response to tamoxifen treatment. As an important part of estrogen synthetic pathways, SULTs are closely re lated to breast cancer.
