PI3K/Akt signal transduction pathway and apoptosis after cerebral ischemia
10.3760/cma.j.issn.1673-4165.2010.07.015
- VernacularTitle:PI3K/Akt信号转导通路与脑缺血后细胞凋亡
- Author:
Min HE
;
Jiangquan HAN
;
Baiyun NI
;
Xianping ZHANG
;
Zhen LI
;
Houqin CHEN
;
Qiang ZHANG
- Publication Type:Journal Article
- Keywords:
1-Phosphatidylinositol 3-kinase;
Proto-oneogene proteins c-akt;
Brain ischemia;
Apoptosis
- From:
International Journal of Cerebrovascular Diseases
2010;18(7):553-558
- CountryChina
- Language:Chinese
-
Abstract:
Apoptosis is one of the important forms during cerebral ischemia.Phosphoinositide-3 kinase (PI3K)/serine/threonine kinase (Akt) is the important cell survival signaling pathway,while c-jun N-terminal kinase (JNK) is the important pro-apoptotic signaling pathway.The dynamic equilibrium of the two signal transduction pathways maintains cell survival and apoptosis under the physiological state.Stimulation during cerebral ischemia breaks this physiological balance and results in the apoptosis of massive neurons.A variety of proved neuroprotective factors are associated with the amplification of enhancement of cell survival signal or inhibition of apoptosis signal,and thrus maintain the balance between the two signal pathways.
