T-type calcium channels and tumor proliferation
10.3760/cma.j.issn.1673-422X.2010.07.006
- VernacularTitle:T型钙通道与肿瘤增殖
- Author:
Wei LI
- Publication Type:Journal Article
- Keywords:
Calcium channels,T-type;
Neoplasms;
Cell proliferation
- From:
Journal of International Oncology
2010;37(7):498-500
- CountryChina
- Language:Chinese
-
Abstract:
Expression of the T-type Ca2 + channels has been reported in numerous types of tumors due to their unique activation/inactivation properties. In some cancer cells, the expression of T-type Ca2+ channels is proliferation state dependent. T-type channel blockers or interfering the α1 subunit of this channel via siRNA decrease proliferation of these cells. Since T-type Ca2+ channels are not expressed in epithelial cells, selective T-type Ca2 + channel blockers maybe serve as a potential therapeutic approach in the treatment of certain types of cancers.
