Telmisartan decreases vascular endothelial growth factor and its receptor expressions in the kidney of insulin resistant rats with normal blood glucose
10.3760/cma.j.issn.1000-6699.2010.09.017
- VernacularTitle:替米沙坦降低血糖正常的胰岛素抵抗大鼠肾脏血管内皮生长因子及其受体的表达
- Author:
Yabin JIAO
;
Li YAO
;
Yanqiu YU
;
Dandan WEI
;
Meina LIU
;
Ling MA
;
Lining WANG
- Publication Type:Journal Article
- Keywords:
Insulin resistance;
Vascular endothelial growth factor;
Telmisartan
- From:
Chinese Journal of Endocrinology and Metabolism
2010;26(9):797-799
- CountryChina
- Language:Chinese
-
Abstract:
The results of RT-PCR and immunohistochemistry showed that the expressions of vascular endothelial growth factor (VEGF) and its receptor ( flk-1 ) in the renal cortex of insulin-resistant rats during the phase of normal blood glucose were significantly increased, which were decreased by telmisartan. The result suggests that telmisartan may ease kidney damage via decreasing VEGF and flk-1 expressions.
