Adjustment of immunosuppressant in pulmonary infection following renal transplantation
10.3760/cma.j.issn.0254-1785.2010.09.003
- VernacularTitle:肾移植术后肺部感染状态下免疫抑制剂的调整
- Author:
Xiaohui LUO
;
Wujun XUE
;
Hang YAN
;
Puxun TIAN
;
Xiaoming DING
;
Heli XIANG
;
Yang LI
;
Yong SONG
- Publication Type:Journal Article
- Keywords:
Renal transplantation;
Pulmonary infection;
Immunosuppressant
- From:
Chinese Journal of Organ Transplantation
2010;31(9):524-527
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between adjustment of immunosuppressant and prognosis in renal transplantation recipients with pulmonary infection. Methods The clinical data of 98 patients with pulmonary infection following renal transplantation were retrospectively analyzed.Patients were divided into two groups: conventional group (n = 45) and immunosuppressant adjustment group (n = 53). The mortality, recovery time and rejection rate in two groups were analyzed under the statement of serious infection (SOFA≥12) and slight infection (SOFA＜ 12) by sequential organ failure assessment (SOFA) score. Results When the SOFA scores ≥ 12, the mortality and recovery time in immunosuppressant adjustment group were significantly lower than in conventional group (P＜0.05), but there was no significant difference in the rejection rate between two groups (P＞0.05). When the SOFA scores ＜11, there was no significant difference in mortality and recovery time between the two groups (P＞0.05). The incidence of rejection in immunosuppressant adjustment group was significantly higher than in conventional group (P＜0.05).Conclusion Mortality could be decreased and course of anti-infection treatment could also be shortened by adjusting the immunosuppressant in renal transplantation recipients with serious pulmonary infection (SOFA≥12). Immunosuppressant agent was proposed to maintain the original treatment protocol when the infection was slight (SOFA＜12).
