Pathophysiological mechanisms and drug treatment of vascular dementia
10.3760/cma.j.issn.1673-4165.2010.08.007
- VernacularTitle:血管性痴呆的病理生理学机制和药物治疗
- Author:
Jie PAN
;
Yun XU
- Publication Type:Journal Article
- Keywords:
Dementia,vascular;
Acetylcholinesterase;
Inflammation;
Oxidative stress;
Cholinesterase inhibitors;
Excitatory amino acid antagonists
- From:
International Journal of Cerebrovascular Diseases
2010;18(8):603-606
- CountryChina
- Language:Chinese
-
Abstract:
Cascade in cerebral ischemic injury may cause cholinergic dysfunction,inflammation and oxidative stress. It plays an important role in the pathological processes of vascular dementia. A large amount of basic research has confirmed that cholinesterase inhibitor and N-methyl-d-aspartate receptor inhibitor may improve cognitive function in patients with vascular dementia. However, the efficacy of these drugs has been confirmed in only a part of the patients, and their safety and efficiency have not achieved the expected results. Thus, it needs further study and exploration.
