C-type natriuretic peptide and long bone growth
10.3760/cma.j.issn.1673-4408.2010.05.002
- VernacularTitle:C型利钠肽和长骨生长
- Author:
Pimei ZHENG
- Publication Type:Journal Article
- Keywords:
Natriuretic peptide,C type;
Long bone growth;
Growth plate
- From:
International Journal of Pediatrics
2010;37(5):446-449
- CountryChina
- Language:Chinese
-
Abstract:
C-type natriuretic peptide (CNP) is an important local regulator of long bone growth. It catalyzes the synthesis of cGMP after binding to its receptor natriuretic peptide receptor-B (NPR-B) ,and regulates long bone growth by activating downstream factors. Though the mechanism of the regulation of CNP signaling remains unclear, it has been demonstrated that CNP signaling has a "cross-talk" with the fibroblast growth factor receptor 3 pathway in cartilate.Heterozygous NPR-B mutations maybe one of the molecular basis of idiopathic short stature. CNP can be used as a biological marker of linear growth, with great importance in growth monitoring, diagnosis and treatment of growth disorders.The research on the mechanism of CNP signaling system in endochondral ossification will contribute to a new medication for bone development disorders in the future.
