The role of incretin in the regulation of glucose homeostasis and treatment of type 2 diabetes
10.3760/cma.j.issn.1000-6699.2010.09.032
- VernacularTitle:肠促胰素在血糖稳态调节和2型糖尿病治疗中的作用
- Author:
Guang NING
- Publication Type:Journal Article
- Keywords:
Incretin;
Glucose homeostasis;
Diabetes mellitus,type 2
- From:
Chinese Journal of Endocrinology and Metabolism
2010;26(9):837-840
- CountryChina
- Language:Chinese
-
Abstract:
Incretins are glucose-dependent insulinotropic hormones that are secreted from intestinal endocrine cells stimulated by meal nutrients after eating. Incretins can maintain glucose homeostasis through promoting insulin secretion from β cell and suppressing inappropriately glucagon secretion from α cell, as well as many other physiological effects. Furthermore, incretins can delay and even reverse the deterioration of type 2 diabetes by enhancing islet β cell function. Incretin-based therapies, including glucagon-like peptide-1 mimetics and dipeptidyl peptidase-Ⅳ inhibitors, will bring us new insights into the treatment of type 2 diabetes.
