Progress in the therapy of glucocorticoid to pediatric ALI/ARDS

VernacularTitle:糖皮质激素治疗儿童急性肺损伤/急性呼吸窘迫综合征的研究进展
Author: Xiaoqiu WANG
Publication Type:Journal Article
Keywords: Glucocorticoid; Receptor; Acute lung injury; Acute respiratory distress syndrome
From: International Journal of Pediatrics 2010;37(5):469-471
CountryChina
Language:Chinese
Abstract: Pediatric acute lung injury/acute respiratory distress syndrome (ALI/ARDS)refers to a special syndrome with high mortality, acute progressive respiratory failure with loss of epithelial and endothelial integrity induced by severe stress reaction and/or inflammation reaction because of pulmonary and/or extrapulmonary diseases.Corticosteroids are routinely used in patients with ALI/ARDS for many years. Corticosterioids play an important role in every link of the therapy of ALI/ARDS because of the effect of anti-fibrosis and anti-inflammation, but it is unclear why the effect of treatment is very different in individual. The use of corticosteroid in the treatment of ALI/ARDS has been subject of great controversy and debate over the years. Recent researches indicate that the effect of glucocoticoids treatment is related with the number and affinity of the receptor for glucocorticoids.