Perioperative anticoagulant therapy in the prevention of deep vein thrombosis after rectal carcinoma surgery
10.3760/cma.j.issn.1007-631X.2010.09.018
- VernacularTitle:围手术期应用抗凝药物预防直肠癌术后下肢深静脉血栓形成
- Author:
Yan LI
;
Jingkui YU
- Publication Type:Journal Article
- Keywords:
Heparin,low-molecular-weight;
Venous thrombosis;
Rectal neoplasms;
Perioperative period
- From:
Chinese Journal of General Surgery
2010;25(9):744-747
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate curative effect and safety of anticoagulant drugs used in perioperative period to prevent deep vein thrombosis (DVT) after rectal carcinoma surgery. Methods Clinical data of 96 postoperative rectal carcinoma cases from January 2006 to June 2009 were analyzed retrospectively.These cases were divided into two groups:48 cases in nonanticoagulant group and 48 cases in anticoagulant group.After radical operation of rectal carcinoma,low molecular heparin calcium was injected subcutaneously daily for 8 consecutive days beginning the day before surgery in anticoagulant group. Results Incidence of DVP in anticoagulant group (4%) was significantly lower than that in noncoagulant group (19%) (x2 = 5.031,P ＜ 0.05).Postoperative hospitalization time in anticoagulant group [(12 ± 3) d] was significantly shorter than that of nonanticoagulant group [(22 ± 6) d] (t = 10.328,P＜ 0.01).There were no significant differences between two groups in operative time,blood loss and postoperative blood drainage,peripheral blood platelet counts before and after operation,prothombin time and active part thrombin time before and after operation,the time when postoperative DVT developes;secondary adverse reactions; postoperative major complication rate and mortality (all P ＞ 0.05). Conclusion Anticoagulant drugs used in perioperative period is safe and effective in prevention of deep vein thrombosis in lower limbs after radical operation of rectal carcinoma.
