GAS/CCK-2R and function of its antagonists in treatment of the pancreatic cancer
10.3760/cma.j.issn.1673-4203.2010.09.011
- VernacularTitle:GAS/CCK-2R及其拮抗剂在胰腺癌治疗中的作用
- Author:
Weibo CHEN
;
Junhua WU
;
Chunping JIANG
- Publication Type:Journal Article
- Keywords:
GAS/CCK-2R;
Pancreatic cancer;
Antagonist
- From:
International Journal of Surgery
2010;37(9):609-612
- CountryChina
- Language:Chinese
-
Abstract:
Studies in recent years revel that there is a close relationship between gastrin/cholecystokinin-2 receptors (GAS/CCK-2R) and pancreatic cancer. CCK-2R is widely distributed in human body, but not in normal exocrine pancreas. However, CCK-2R is abnormally expressed in pancreatic carcinoma. The abnormal expression of CCK-2R in pancreatic tissues leads to the abnormal protein expression and activation, changes in acinar cells' morphology and phenotype and an increase in the sensitivity to carcinogenic substances. And some GAS/CCK-2R antagonists can be used for the early and late treatment of pancreatic cancer.
