A clinical analysis of anti-neutrophilic cytoplasmic antibody associated microvasculitis with gastrointestinal tract hemorrhage
10.3760/cma.j.issn.1007-7480.2010.09.007
- VernacularTitle:以消化道出血为主要表现的抗中性粒细胞胞质抗体相关性血管炎临床分析
- Author:
Jing ZHAO
;
Dong XU
;
Hong YANG
;
Mengtao LI
;
Fengchun ZHANG
- Publication Type:Journal Article
- Keywords:
Gastrointestinal hemorrhage;
Wegener's granulomatosis;
Vasculitis;
Antibodies,anti-neutrophil cytoplasmic
- From:
Chinese Journal of Rheumatology
2010;14(9):610-613
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the clinical characteristics and prognosis of ANCA associated microvasculitis patients with gastrointestinal tract hemorrhage. Methods A retrospective analysis was conducted in 8 ANCA associated microvasculitis patients with gastrointestinal tract hemorrhage admitted to our hospital from May 1987 to May 2007. The statistical treatment is Kaplan-Meier. Results This group contained 4 male and 4 female patients. The average age was (39±20) years. The time from the onset of their disease to gastrointestinal bleeding was (8 ±8) months. Wegener's granulomatosis was the most common disease.Hematochezia(7/8 ) was the most common clinical manifestation and the distal small bowel (5/8) was the most common involved site. After the diagnosis was confirmed, methylprednisolone bolus therapy was used in 2 patients and 1～2 mg·kg-1·d-1 prednisone in 6 patients. Surgical operations were performed for 3 patients.However, 5 patients died. The prognosis was poor with the average survival time of (373±108) days. The mean survival time was (46 ±10) days after bleeding. Conclusion ANCA associated microvasculitis with gastrointestinal tract hemorrhage is rare. Early diagnosis and treatment could improve the prognosis.
